Trump announced the firing in a tweet, saying he had informed Bolton his "services are no longer needed". Clearly, he was opposed to Trump's Taliban outreach through his special representative for Afghanistan Zalmay Khalilzad, and although the expected finale in Camp David bombed, Bolton was not behind the prospective deal.
Trump's decision to pull out of peace negotiations capped a tough week.
Bolton is a notorious hawk, especially in the middle east. Bolton had supported carrying out the US attack.
Futures fell as much as 1% to $57.30 a barrel following the announcement.
Trump will soon appoint the fourth national security adviser of his first term, with Michael Flynn and H.R. McMaster having served and departed. He masterminded a quiet campaign inside the administration and with allies overseas to convince Mr. Trump to keep US forces in Syria to counter the remnants of the Islamic State and Iranian influence in the region. He was later was a Fox News contributor and senior fellow at the conservative American Enterprise Institute.
"There were definitely places that Ambassador Bolton and I had different views about how we should proceed".
President Trump fires National Security Adviser John Bolton
Trump has also seemed increasingly uninterested in speaking about Venezuela, a major cause for Bolton who wants to oust leftist leader Nicolas Maduro.
USA officials have said it was Mr Bolton who was responsible for the collapse of a summit in February between Mr Trump and North Korean leader Kim Jong Un in Hanoi by recommending the presentation a list of hardline demands that Kim rejected.
Bolton, in response to Trump's tweet, said he offered his resignation Monday night.
These kinds of differences between Trump and Bolton eventually spun the two men too far apart.
The Bolton resignation also was covered by news break ins by the broadcast networks, in the latest tumult to come out of the White House. At left is then-National Security Adviser John Bolton.
Bolton was among the officials who urged Trump to fire Nielsen.
But just 20 minutes afterward, Bolton - a consummate insider despite his contempt for the establishment - hit back with his own tweet and text messages to reporters, already showing daylight with Trump by saying that he had quit on his own. Bolton reportedly was instrumental in shaping Trump's tough Iran policy even before he reentered the government.
At rally, Trump paints bleak picture of Democratic control
Mr Sanford criticised Mr Trump during the 2016 presidential election but ultimately supported him. Parscale later elaborated on his comments by telling reporters, "I just think they are a dynasty".