Isco struck at the death to send Real Madrid six points clear of Barcelona at the top of La Liga after twice coming from behind to beat Sporting Gijon 3-2 on Saturday.
Isco popped up again in the final minute of normal time to seal the victory and cap a fraught 90 minutes for Real, who are now six points clear of Barcelona in second, ahead of next weekend's crucial El Clasico.
Sporting, who started the day five points adrift of safety, had gone ahead on 14 minutes through a volley from Croatian forward Duje Cop, but Real were soon level when midfielder Isco drilled the ball into the top corner.
Sporting retook the lead five minutes into the second half as Vesga looped a measured header into the far corner.
"Isco played really good today and with Bale's injury he may enter in the line-up against Bayern Munich:" He played really good today.
Zidane spoke at press conference after the important victory Real Madrid achieved against Sporting Gijón in the31st week of the regular season.
"Isco? He had a great game and deserved it", the Coach said after the game.
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Messi is now just two goals away from his 500th for the Spanish club.
Nevertheless, Zidane is putting his eggs in the Champions League quarterfinals basket, when Bayern Munich will be looking to overturn a 2-1 deficit on Wednesday.
Madrid's domination was becoming increasingly evident and Marcelo, who had come on in place of Coentrão, came close to rewarding the leaders' superiority with a strike from the edge of the area after a sublime piece of play from Isco on 72′.
Madrid twice fought back from a goal down against the relegation-threatened side at the Santiago Bernabeu on Saturday, before Isco's 90th-minute victor kept them on track for a first league title since 2012.
"I am at the best team in the world, there is no bigger team than Madrid and I feel fortunate", said Isco.
It was the sixth time this season that Zidane's team had won with a goal inside the last 10 minutes, but he said: "In football there is no luck - there is a lot of hard work. I don't understand why people are surprised when I say I want to play more, If I'd think I don't deserve it I wouldn't say that".