The film will still hope to accumulate a fair taking from across all worldwide markets, so perhaps it's too soon to call this a flop, but it does show there was perhaps a little too much faith shown in the sequel to a film a lot of people might have fibbed about ever having seen.
Besides, who knows, Blade Runner 2049 might jump into the Academy Awards the same way George Miller's dystopian science fiction movie Mad Max: Fury Road did back in 2015.
According to PostTrack, males over 25 represented 50 per cent of the audience and females over 25 were 27 per cent, while males under 25 represented 15 per cent of moviegoers and females under 25 were 8 per cent. Males gave the movie an A CinemaScore, while females gave it a B+.
The horror film It, adapted from a book by the master of horror Stephen King, is third with $ 10 million, more than 305 million in five weeks.
"Blade Runner 2049", starring Harrison Ford and Ryan Gosling, opened with $32.7 million at the box office, according to comScore. Denis Villeneuve helms the sequel film, which is set in a bleak 2049 Los Angeles with Gosling starring as an LAPD officer dealing with replicants seeking freedom. "It's a tough one, because Denis made a handsome movie", Warners domestic distribution chief Jeff Goldstein said. It's a tough one, because Denis made a handsome movie. "The audience for it was narrower than we anticipated". "Where we did do business was in the major markets".
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Blade Runner 2049 is ahead of another new entrant in the rankings: The mountain between us, from Hany Abu-Assad, in which two strangers - Kate Winslet and Idris Elba - are trying to get out after the crash of their small plane in the middle of a chain of snow-capped mountains, with little hope of being rescued. Directed by Hany Abu-Assad, the United States dollars 35 million film tells the tale of two strangers who are stranded in the wilderness after surviving a plane crash. On Rotten Tomatoes it has a certified fresh score of 88 percent from 253 critic reviews.
The animated My Little Pony trotted in with a modest US$8.8 million, slightly above forecasts. The feature film to the hit children's TV show stars the voice work of Emily Blunt, Kristin Chenoweth, and Uzo Aduba.
Made on a budget of $150m, typically studios spend roughly $100 million again on marketing, meaning to be profitable Blade Runner 2049 needs around $250m.
"Flatliners" ($4 million) and "Battle of the Sexes" ($2.6 million) rounded out the top 10.