In his remarks after Otto's death, US President Donald Trump offered condolences to the Warmbier family and denounced North Korea as a "brutal regime" with no respect for "basic human decency".
The American doctors who watched Valmiera, said that he has serious brain damage.
North Korea had claimed that the student got botulism and was given a sleeping pill, leaving him in the coma. Officials from the University of Cincinnati Medical Center, which treated the student upon his return, labeled his condition as a "state of unresponsive wakefulness".
The funeral will be held at 9 a.m.at Wyoming High School, where Warmbier was an athlete and salutatorian of his 2013 class.
His family says it was told he had been in a coma since soon after his sentencing.
The University of Virginia honours student's parents, Fred and Cindy, who live in Wyoming, Ohio, said in a statement that their son, 22, had "completed his journey home" and "was at peace" when he died on Monday at 2.20 p.m., reports The New York Times.
Doctors last week declined to speculate on what may have caused Warmbier's condition.
Doctors in the United States say Mr Warmbier suffered an extensive loss of brain tissue; while his eyes opened and blinked, there was no sign he understood verbal commands or his surroundings.
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"The United States once again condemns the brutality of the North Korean regime as we mourn its latest victim", Trump added.
They found no evidence of botulism or that Mr Warmbier had been physically assaulted.
The company runs its North Korean tour out of Yangshuo, China with its tours beginning and ending in Beijing, according to the agency's website. He was leaving North Korea on January 2, 2016, when he was detained at the airport.
Young Pioneer Tours said on its Facebook page Tuesday that the death of the 22-year-old Warmbier shows that the risk American tourists face in visiting the isolated nation "has become too high".
But North Korea has also consistently lobbied Washington for specific concessions that would need deep negotiations, something recent USA administrations have been reluctant to pursue because of the North's weapons programs.
The organizers of Warmbier's trip say they will no longer take US citizens to the country. While almost all Americans who have been there have left without incident, visitors can be seized and face lengthy incarceration for what might seem like minor infractions. Warmbier, an American college student who was released by North Korea.
Bae went home in November 2014 after a secret mission by the USA intelligence chief at the time, James Clapper, secured his release, as well as that of Mathew Miller, another American detainee. Both the US and South Korea - North's adversaries - have their citizens trapped in Pyongyang jails.
Bae, a Korean-American missionary from Lynnwood, Washington, was imprisoned for more than two years after North Korea charged him for anti-state activities.
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