Spurs had the opportunity to move one point behind leaders Chelsea in the Premier League title race last night but an unusually flat performance resulted in a 1-0 defeat at the London Stadium.
Spurs' Premier League title aspirations were dealt a shattering blow at the London Stadium after Manuel Lanzini scored in the 65th minute.
The Gap now stands at four points, but Chelsea can extend their lead back to seven points with a win against Middlesbrough on Monday.
"To win a league or a trophy is about key moments", said Pochettino.
"There's similarities with the Chelsea game last season [a 2-2 draw that guaranteed Leicester's status as champions] but we've really given it a good go this year".
"If you want to be a champion you have to win. How?"
"If you win the league, you learn".
"We have one week to prepare well for this game, put in the right energy and try to finish unbeaten at home". It is disappointing with the result, now we wait for the Chelsea result then it's three games ahead to play.
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Antonio Conte's men are in action twice before Spurs play again and, if they beat Middlesbrough and West Brom, they will be champions before Pochettino's side return to action next Sunday at home to Manchester United.
After initially blocking a shot from Spurs striker Harry Kane, Adrian stuck out a foot second later to deny Kane a second time.
"It wasn't our best day", added Pochettino. "The performance was just ok", he said. "But we need to try - always to the end, always".
West Ham were quick to close Alli down and he had to be clever to find pockets of space. "I think today I think we missed a bit of something".
"It was a hard game, it's true that if you compare it with five days ago against Arsenal it was not the same performance that we played last week".
For all the talk of its lack of atmosphere, as Lanzini smashed home the second-half victor a roar went up like nothing heard at this venue since Mo Farah came down the final straight in 2012. "With Mousa we lose and we win with different players".
"We managed to bring it back to four points but after today, it's almost impossible, but we will give it everything for the last three games", added the 23-year-old England global. Great determination, thinking about what each individual had to do.
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