Cramer was played a clip of Spicer again apologizing for saying of Assad, "you had someone who was as despicable as Hitler who didn't even sink to using chemical weapons".
"Frankly, I mistakenly made an inappropriate and insensitive reference to the Holocaust, for which there is no comparison".
"Horrible example. I believe he appropiately apologized, but it's really going to be up to the President. It was a mistake to do that".
He noted that Trump had bombed a Syrian air base in a forceful response to chemical weapons use by Assad's government and said Trump's hosting of Chinese President Xi Jinping last week had produced "tremendous progress".
I think when you come to sarin gas, there was no, he was not using the gas on his own people the same way that Assad is doing.
In a statement to White House reporters, Spicer said in no way he was trying to lessen the horrendous nature of the Holocaust. Eighty-seven people, including children, were killed in last week's chemical weapons attack in Syria.
Pence tours Southeast Asia's largest mosque
In Trump's first 100 days in office, Pence noted, the new president has taken steps to strengthen America's military. KORUS, which was signed five years ago, provides duty-free access for 95 percent of consumer and industrial goods.
Democrats and Jewish organisations condemned Mr Spicer's comments.
Zeeland Congressman Bill Huizenga says he feels Spicer was not trying to use the comment lightly as an example, but trying to underscore the atrocities in Syria.
When asked whom he was directing his apology to, Spicer said, "anyone offended by the comments".
"The problem with Sean Spicer and this administration is, they don't have the DNA of compassion and they don't have the DNA of the knowledge of history and I come from a people who lost 6,000 people a day gassed in Auschwitz - any sixth-grader knows what Sean Spicer should know", he added.
The White House generated criticism at the start of the year when a statement on worldwide Holocaust Remembrance Day did not make any reference to Jews.
White House Press Secretary Sean Spicer speaks during "The President and the Press: The First Amendment in the First 100 Days" forum at the Newseum in Washington, DC, April 12, 2017.
The Nazis murdered six million Jews during World War Two.