Rojo was stretchered off during the first-half of United's 2-1 win over the Belgian side in Thursday's Europa League quarter-final tie with multiple reports suggesting the Argentina global will miss the rest of the season having suffered a ruptured cruciate ligament injury.
"The injuries are really big", he told Sky Sports prior to the win over Burnley.
Jose Mourinho insisted "I don't care" whether Zlatan Ibrahimovic plays again or not after revealing his sadness for the injured Manchester United striker, who faces up to nine months on the sidelines and may have played his final match for the Premier League club.
United are still determining how long Rojo and Ibrahimovic will be out for and will gather "specialist opinions" in the coming days.
Rooney added: "I've picked up a few injuries which is frustrating, nothing big but small injuries which have set me back (but) I've come back, I feel strong and I'm thankful to have played today and to have scored". "We play another one and we don't cry". One thing is for sure, I decide when its time to stop and nothing else.
Instant analysis: Marc-Andre Fleury, Penguins struggle in Game 4 loss
What will decide Tuesday night's game? The Penguins responded to pull within one again at 2:10 of the third on Kuhnhackl's goal. F Matt Calvert also was back after serving a one-game suspension for breaking his stick over the back of Kuhnhackl on Friday.
"No player deserves to be injured but I think in this case it's even more sad because Zlatan, in this stage of his career it's really, really hard, and Marcos probably at this moment in his career is playing very well for us and also finally getting a position as central defender in the global team, so we're really sad for them".
"We have to respect that but they are important injuries". Giving up is not an option.
"(Bailly) was incredible. If I was Smalling or Jones, I would play Thursday.
Given how crucial these individuals have been and have become over the course of the season, losing them at such a pivotal time of the campaign will be a major body blow for Mourinho and the club. "I would do a last push", he said. If they are safe thinking and they are surrounded by people with the same mentality they have, it is more time, more cautious.
The timing couldn't be worse for Mourinho, with United still competing for a place in the Champions League next season and in the semi-final of the Europa League. "In terms of expectation, in terms of emotion for the game, it's better for a derby with one point difference than with four".
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