The March for Science was dreamed up at the Women's March on Washington, a day after President Donald Trump's inauguration in January.
Marchers evidently felt science and the scientific method is under attack. Retired Northern Illinois University professor Charles Cappell waved a flag showing an image of Earth from space, saying it represented unity of everyone belonging to the same solar system.
Bristol, Edinburgh, Manchester and Norwich were also due to host marches at the same time.
Nye is now the CEO of the Planetary Society- one of the march's partners- and star of the new Netflix series Bill Nye Saves the World.
Scientists rallied around the world on Earth Day in part to protest the Trump Administration's policies on science and climate. It was a peaceful demonstration, said Pati Vitt, a plant scientist at the Chicago Botanic Garden in town for work at the university.
March organizers are also anxious by what they see as growing skepticism from politicians and others on topics such as vaccinations, genetically modified organisms and evolution.
Mr Trump, who has previously claimed that climate change is a hoax "invented by the Chinese", later took to Twitter to argue that growth in the economy boosts the protection of the environment.
Dr. Ed Miller, a participant at the march, says funding for science is important because without funding, science would not be possible. "So if we stop funding scientific discoveries now, in 10 years, whatever we might have had won't be, we just won't have it".
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Paleontology student Jade Simon said she was marching for fact-based policy at the March for Science Toronto on Saturday.
In cities like Seattle, Chicago and NY, thousands gathered in support of the movement.
"My administration is committed to advancing scientific research that leads to a better understanding of our environment and of environmental risks", the statement added.
Critics like Mann see the Trump administration's cutbacks at the Environmental Protection Agency and other government programs as a serious threat. "Our lawmakers must know and accepts that science serves everyone of us".
Scientists and their supporters were urged to turn out in force in London as well as other marches in France, Ireland, Finland, Germany, Portugal and the Netherlands.
Still, the marches were effectively protests against steep cuts that President Donald Trump has proposed for federal science and research budgets and his administration's skepticism about climate change and the need to slow global warming.
"So numerous most important issues of the day- Climate change and human health just to name 2 specific ones, and right now, science is under some threat", said Futter.
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