Nadal dropped a set in the second round against Kyle Edmund but was ruthless as he dispatched another young gun, the 20-year-old Zverev who was reduced to trashing rackets in frustration against the Spaniard.
Ramos-Vinolas progressed to the fourth round on the Monaco clay for the first time at the French Open warm-up event.
"If I was to play Budapest or Barcelona and do well, I would not really have a chance to train much between now and the French Open".
Djokovic saved the first match point with an ace; the second one on his second serve; the third with a stinging forehand victor and a fourth when Goffin chopped a backhand into the net.
Nadal had never lost more than four games in a set in his opening match at the tournament but, after breezing through the opener, was blown off course by the power of Edmund's forehand.
"He seems to be", said Murray.
With 30-somethings Federer and Nadal apparently in remission, with Djokovic scuffling by his magnificent standards, here was a yawning opening at the top of men's tennis. Next up for him should be next month's Madrid Masters, where he was the runner-up in 2016. He was handed a first-round bye in the first European claycourt tournament of the season. However, he didn't face anyone ranked higher than Lucas Pouille's No. 15.
Top foreign policy moments of Trump's 1st 100 days
That compares to the 35 perent who say the president's first 100 days have been "good" or "great", according to the NBC/WSJ poll . Republicans' apparent lack of concern about the deficit prompted Democrats to call them out. "They've been all over the map".
A couple of things can happen when you become the No. 1 player: First, especially early on, there's a self-imposed pressure that comes with the ranking.
"If you hesitate a little, he will get you", Wawrinka said.
The result was all the more painful for the Brit given he held a 4-0 lead in the deciding set but a late collapse allowed the Spaniard to record his first win over a world No. 1.
"Before the match, I thought it was going to be a big test for me, a very hard match", admitted Nadal. However, the Scot was outclassed in the second set, as Ramos-Vinolas produced some stunning play to level.
"I wasn't going to play if I didn't feel like I could serve properly", Murray added. "Sometimes having a break, if you're feeling exhausted or worn out is great. I normally beat guys by maneuvering them around the court rather than blasting them off the court", he said. "That's something that, with my team, I'll look at, watch some parts of the match over, see the shots that I chose and what I would do differently".
The good news for Murray and his fans?
Murray struggled to overcome Gilles Muller in the last 32 on Wednesday and after a inconsistent start, he took control of the first set against Ramos-Vinola racing away from 2-2 to take it 6-2.
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