Praneeth fought hard to get the better of Thai eighth seed Tanongsak Saensomboonsuk 15-21 21-14 21-19 in an hour and 11 minutes.
Marin, who climbed a spot to number two in the latest rankings, will fancy her chances against World No. 5 Sindhu, who has looked jaded since her win at the India Open and has had to battle over three games to win in her previous two rounds.
The second and third game saw Sindhu at her best.
The fourth seed just needed 27 minutes to decimate Chinese Taipei's Chia Hsin Lee 21-7, 21-11 in the second round yesterday.
Sindhu will now take on Spain's Carolina Marin, whom she defeated in the summit clash of the India Open earlier this month.
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Olympic silver medallist PV Sindhu and ace male shuttler Kidambi Srikanth registered contrasting victories in their respective events to make it to the second round of Singapore Open Superseries, here on Wednesday. Sindhu trailed 5-11 at the break. The Spaniard had lost her last two matches against Sindhu since their clash at the Rio Olympics previous year. The Chinese duo, who won the All England Open and the Indian Open earlier this year, have been the most consistent pair on the mixed doubles circuit this year, having won 17 of the 19 matches that they've played.
The opening game started aggressively with Marin being quicker off the blocks in fast-paced rallies. The score switched from 10-4 in favour of Marin to 16-4 and the crowd completely remained at awe with her showing.
At that point, Sindhu did try making a comeback as she won quite a few points, thanks to some challenges going her way and her smashes doing the talk.
Sindhu, on the other hand, miscued her shots even as Marin sealed an 11-4 advantage with a smash on the Indian's backhand.
Sindhu then handed over the match to the Spaniard with a service fault, summing up an unusually bad day for her. He moved to a 15-9 lead and then reeled off four points at 17-14 to grab the first game.
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