A second patient 'cured' of HIV. But consider what it took

Adjust Comment Print

The Berlin patient, the first person who was completely cured of HIV, had a similar bone marrow transplant in 2007 and has since been HIV free.

HIV is the virus that causes AIDS.

Those with the HIV-resistant mutation "CCR5 delta 32" are mostly of Northern European descent. In both cases, the bone marrow was taken from donors with natural resistance to HIV because of a genetic mutation in two copies of their CCR5-delta 32 gene, which encodes a critical protein that allows HIV to enter and infect cells.

Since 2008, scientists have been trying to replicate the treatment that cured the "Berlin patient" of HIV. This news comes almost 12 years after the first patient was known to be cured and scientists have struggled to replicate the results ever since. In these two cases, doctors selected a donor who had an uncommon mutation that made them virtually immune to HIV infection and this mutation was passed on to the recipient.

Later that year, he was diagnosed with advanced Hodgkin's Lymphoma, a deadly cancer. Outlining possible explanations for these unsuccessful attempts, the Post's Johnson says that stem cell transplants are often used as a last resort, and only in cases where a clinical issue such as cancer is present.

He did not experience HIV rebound, during the 18 months he did not take anti-viral medication.

The patient known as the "London Patient" received a stem-cell transplant that replaced their white blood cells with HIV-resistant versions. However, because HIV remained undetectable, he is still considered clinically cured of his infection, according to his doctors. An estimated 37 million people are now living with HIV around the world and more than two-thirds (70 percent) of all people living with HIV, 25.8 million, live in sub-Saharan Africa. With an HIV prevalence of 0.26 per cent in the adult population, India has an estimated 2.1 million people with HIV, shows UNAIDS data.

Woods pulls out of Bay Hill with neck strain
"My No. 1 job is to captain that team and do that the right way, but then I want to be able to come out here and play", he said. Tiger Woods set golf's alarm bells ringing on Monday night by pulling out of this week's PGA Tour event with a neck injury.

The report describes a male patient in the United Kingdom, who prefers to remain anonymous, and was diagnosed with HIV infection in 2003 and on antiretroviral therapy since 2012. Prof Ravindra Gupta cited the unethical research by the Chinese scientist where he created designer babies with the CCR5 gene-editing to make them immune to HIV.

A person recognized exclusively because the "London affected person" seemed to be cured of H.I.V., making him the second recognized affected a person in practically 12 years, giving scientists new hope that an eventual treatment is feasible, studies stated Monday.

The German patient had also received a bone marrow patient.

Scientific investigation into the world's second man cleared of the AIDS virus is zooming in on a gene and a treatment side-effect, as newly-enthused researchers strive to find a cure for the disease that has killed millions.

The new patient, who was treated...

"The so-called London Patient has now been off ART for 19 months with no viral rebound which is impressive, but I would still be closely monitoring his viral load", Sharon Lewin, IAS Governing Council Member and Co-Chair of the Towards an HIV Cure initiative, said.

Graham Cooke, a professor of infectious diseases at Imperial College London, said in a statement to the Science Media Centre that the new study is "encouraging".

Comments