Olivier Giroud headed a consolation for Chelsea but they dropped below their north London rivals in the table after suffering a first top-flight loss of the season.
Harry Kane of Tottenham Hotspur is challenged by Antonio Ruediger of Chelsea.
"I don't think [it would have changed things]", he said.
In keeping with recent weeks, Liverpool were far less impressive but remain on City's coat-tails as Mohamed Salah, Trent Alexander-Arnold and Roberto Firmino all struck in the final quarter at Vicarage Road.
Raheem Sterling scored and set up two more in Manchester City's 4-0 win over West Ham.
Tottenham have won their last six London derbies to build confidence and momentum ahead of Saturday's top-four clash. This was the first problem but today I saw a lot of problems because we played very badly from a physical point, of view, mentally, technically, tactically, particularly in the first 20 minutes. "But I still think Arsenal, West Ham or Chelsea are our biggest rivals".
The Dane has created 108 chances since the start of last season, which is the same amount as Kevin De Bruyne and more than Mesut Ozil (104).
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This game won't be played in South Bend, thanks to an Irish scheduling job, so the game will be played at Yankee Stadium . He has completed 63.9 percent of his passes in eight starts, throwing for 1,897 yards and 15 TDs with five interceptions.
"We have to try to do something, because the defensive phase today was a disaster", he said.
The only downside was captain Jordan Henderson being shown a red card for two bookable offences, yet Klopp was more focused on his side's spirit. Leroy Sane too stomped his authority in the game hitting a goal in each half to make it 4-0 for his side.
Chelsea expect to have Eden Hazard back at full strength after he returned to the starting XI against Everton, while Sarri expects Mateo Kovacic to be available despite the ankle problem that sidelined him for Croatia's defeat to England in the UEFA Nations League on Sunday.
Chelsea were unable to stem the tide as their 12-game unbeaten league run came to a crashing halt when Son danced through the visitors' defence to score a superb third in the 54th minute. However, it was a different scenario for Manchester United which failed to capitalise on chances presented to it and played a drab goalless draw with Crystal Palace.
Everton moved above Manchester United into sixth thanks to a 1-0 win over Cardiff, with Gylfi Sigurdsson snatching the victor just after the hour mark. We did not win one point, we lost two.
'The problem was that the opponents were more aggressive, more determined than us, ' he added.