Tuesday's numbers were 03-45-49-61-69 (09).
It costs $2 to play the game, but the odds of instant wealth aren't good.
Mega Millions is played in 44 states as well as Washington, D.C., and the U.S. Virgin Islands.
Ashley Eggen of Elizabethtown, Kentucky, won $1 million playing Mega Millions on Oct 9.
Trump says missing Saudi journalist Jamal Khashoggi appears to be dead
In what the Post called his last piece for the newspaper, Khashoggi drew criticism on the Middle East's lack of a free press. Khashoggi vanished after entering the consulate for official documents ahead of his upcoming wedding to his Turkish fiancee.
While nobody matched all six numbers, the California Lottery tweeted Tuesday night that one ticket sold in San Francisco matched five numbers.
You could be $667 million richer if you happen to win the Mega Millions jackpot.
After going without a victor since July 24, the Mega Millions game has now reached an all-time high at $667 million. "I thought they would buy two to three at a time, but they're buying 10-20 dollars' worth a time, it's insane", said Bishop.
If someone wins big in this week's lottery, they'll not only be set up for life. "I mean, I am struggling to pay bills big time so it would definitely be helpful". "Just live a normal life". The odds of getting all six of numbers for that game is 1 in 292 million. The increase from $654 million reflects a surge in ticket sales.
Wednesday's Powerball jackpot is nothing to sneeze at either. The next Powerball drawing will be held Wednesday at 10:59 p.m. ET and tickets also must be purchased by 10:00 p.m. that day to be eligible.