An estimated 43 per cent of the 20.7 million French people who voted for him on Sunday did so to register their rejection of the anti-European Union, anti-immigration Ms Le Pen rather than their support of him and his policies.
German Chancellor Angela Merkel's spokesman said it was a "victory for a strong and united Europe", while EU Commission President Jean-Claude Juncker said French voters had chosen a "European future".
President Donald Trump took to Twitter to congratulate Macron on his "big win".
Macron's lead after the election's first round never dipped below the high teens, and it probably shouldn't shock anyone that France is about 10% less enamored of the idea of rounding people up and shipping them away than we are in the USA, what with having experience doing so-regardless of Le Pen's reinterpretation of that particularly unpleasant moment of French history. This may not go over very well, given that, in the second round, nearly 60% of French people voted for Le Pen or didn't vote at all-and the latter we presumably not casting a silent vote of support for Macron and the invisible hand.
In Moscow, Vladimir Putin would have hailed the beginning of a new era with the redrawing of Europe's political map - a "civilisational" Russian victory over western values.
The president-elect made his comments in a speech to supporters at campaign headquarters in Paris less than an hour after Le Pen conceded the election.
"If Macron fails, then the next president will be Marine Le Pen and we need to prevent this at all costs", he added.
Pentagon says it will arm Syrian Kurds, despite Turkey's objections
When asked whether the new arms deal with the YPG could put US forces in danger from Turkish airstrikes, Pentagon spokesman Maj. On Monday, a high-ranking group of Turkish officials was informed of the decision by White House national security adviser H.R.
The outcome will help restore some of the EU's self-confidence after it was battered by Britain's decision to leave the bloc past year.
Still, the shape of French politics isn't settled yet.
Macron's positions on Israel, its conflict with the Palestinians and the Middle East in general correspond with those of the government of France's outgoing president, Francois Hollande, Macron told a predominantly Jewish crowd in March during a town hall meeting organized in Paris by CRIF. His lack of an established base may curtail his ability to fulfil campaign pledges to pursue closer ties to France's European neighbours and launch far-reaching reform of the economy. One explanation for this, still embryonic, is that a generation old enough to remember the consequences of fascism for France is likely to be more consistently inoculated against the appeal of the far right. In August 2014, Hollande named him economy minister within his Socialist government.
On Monday, key members of the centrist arm of The Republicans appeared ready to work with Macron despite the party hierarchy calling for unity to oppose the new president and calling those that were wavering "traitors". In June, two more rounds of voting will determine the make-up of France's 577-seat parliament.
At 39, Macron will become France's youngest leader since Napoleon when he is inaugurated on Sunday.
Initial estimates showed Macron winning between 65 percent and 66.1 percent of the ballots - a higher than expected score - and Le Pen scoring between 33.9 percent and 35 percent.
But for now at least, the president-elect can rest assured that his victory over Ms Le Pen - however qualified - was emphatic.
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