But Sunday's strike was the first known missile attack launched from Iran into foreign territory since the Iran-Iraq war of 1980-88.
Two U.S. officials said Iran fired six ballistic missiles during the attack - one Fatah-110 and five IRSS-1 "Zulfiqar" missiles.
The countermeasure killed dozens of Daesh terrorists, including six of the group's Libyan commanders, with one of the missiles reportedly hitting a Daesh command center in the province's city of al-Mayadin.
On Tuesday, Iranian Defense Minister Brigadier General Hossein Dehqan said the missile strike was just a small part of the Islamic Republic's reaction to the "indiscriminate" attacks by the terror group on the Iranian soil.
Hours after the Iranian attack against ISIS, President Trump authorised his forces to shoot down a Syrian government fighter jet.
President Donald Trump has ordered stepped-up military operations against Islamic State and delegated more authority to his generals, but without a comprehensive Syria strategy, his approach risks further confrontation with Syria, Iran and even Russian Federation, according to USA officials and analysts.
Iran's missile strike this week against Islamic State targets in Syria is escalating its military involvement in Syria and likely will heighten tensions between the US -led coalition and Russian and Iranian forces aligned with the Syrian regime, analysts say.
In fact, it is more likely that the Iranian Regime attempted to attack this province, without caring who would get hurt, because they wanted control of it.
But he warned that Iraq "should not trust" the United States, which is leading a coalition fighting IS in Iraq and neighbouring Syria.
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The Guards website said it launched surface-to-surface medium-range missiles targeting the area.
It also raises questions about how U.S. President Donald Trump's administration, which had previously put Iran "on notice" for its ballistic missile tests, will respond.
The Zolfaghar missile, unveiled in September 2016, was described at the time as carrying a cluster warhead and being able to strike as far as 700 kilometers (435 miles) away.
Iran's larger, longer-range missiles have struggled with accuracy problems in the past, as many lack global positioning satellite receivers. Islamic State (IS, formerly ISIS/ISIL) claimed responsibility for the attacks.
The twin attacks were claimed by the IS group.
Russian Federation reacted angrily to the USA shootdown of the Syrian jet, which the Pentagon said was dropping bombs near the US -backed Syrian Democratic Forces, a mixed Kurdish-Arab militia fighting Islamic State.
It is the first time the USA military has downed a Syrian aircraft since the civil war began in 2011, officials said.
"Iran is trying to play at being a great power", explained Channel 2 Middle East analyst Ehud Ya'ari.
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