Numerous victims are believed to have just left evening prayers at a Muslim Welfare House after breaking the Ramadan fast.
The driver of the van, a 48-year-old man, was found at the scene and detained by the public until police arrested him.
United Kingdom's Prime Minister, Theresa May, announced that the police were treating the incident "as a potential terrorist attack".
Witnesses said the man was white.
The van hit people just after midnight local time who were attending to a man who had collapsed in the street. Most of those hit were said to have been aiding an elderly man who was already lying on the ground suffering from what is thought to have been cardiac arrest. A mob surrounded him and witnesses said the crowd began attacking him.
Mohammed Kozbar said the attack early Monday morning was no different than the recent attacks on London Bridge and Manchester Arena and said the Muslim community is "in shock". Vehicles have also been also used to attack the public on London's Westminster Bridge, in Nice, France, and in Berlin.
If confirmed by authorities as terrorism, this would be the fourth such attack in Britain since March and the third to involve a vehicle driven at pedestrians.
Leaders at the facility - which provides support services for Muslims in the North London area - quickly condemned the attack, referring to it as an "act of hate" meant to drive the community apart.
In a statement, the police say they were called to the Seven Sisters Road by reports of collision with pedestrians.
"He turned left into the alleyway, and he just drove at people", eyewitness Abdiqadir Warra told AFP. The statement says: "One man was pronounced dead at the scene".
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The driver of the van jumped out of the vehicle and tried to run, Aidroos said.
"Some big van. crushing the people in the mosque".
"We want to go out and integrate into society and show people that Islam is peace".
After being seized, the man said he had wanted to kill "many Muslim people", one witness told journalists.
"He punched me in the head", Hashi said, showing his bruises. CNN spoke to a man at the company, who said he was the owner but declined to give his name. "We stopped the guy and we put him on the floor and people managed to call police", Hashi said, showing CNN his bruises.
"During the night, ordinary British citizens were set upon while they were going about their lives, completing their night worship. My prayers are with the victims and their families", read the statement. This comes near the end of Ramadan, the holiest time of the year for Muslims.
She hailed the "bravery" of locals for detaining the driver at the scene in the north London district of Finsbury Park.
That attack came in the wake of a suicide bombing outside an Ariana Grande concert in Manchester last month that killed 22. "He looked indifferent - he knew what he was doing", said another eyewitness, 18-year-old Abdul Abdulahi. The Westminster Bridge attack was similar but the attacked used a auto, not a van. Police believe the rampage is inspired by Muslim extremist ideology.
The council also clarified that the incident took place outside the Muslim Welfare House, 300 meters away from the mosque.
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