The Damascus International Airport lies about 25 kilometres southeast of Syria's capital.
An Israeli defense official said the Patriot hit a drone, and the military is checking if it was a Russian aircraft that entered the Israeli side by mistake or if it was Syrian.
But Intelligence Minister Israel Katz, speaking to Army Radio from the United States, appeared to confirm involvement.
'The prime minister has said that whenever we receive intelligence that indicated an intention to transfer advanced weapons to Hezbollah, we will act'.
Turkish President Recep Tayyip Erdogan, Netanyahu said: "Iran is trying to establish itself permanently in Syria, with a military presence on the ground and at sea, and also a gradual attempt to open a front against us on the Golan Heights".
Commenting on the reports, Israeli Intelligence Minister Yisrael Katz said that the strike was compatible with Israel's policy of targeting streams of Lebanon-based Hezbollah's Iranian arms deliveries through Syria.
It was hit by Israeli air strikes in December 2014, Syrian state media reported at the time.
Hezbollah, considered by Israel a terrorist organization, was established in the 1980s in Lebanon.
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China has dismissed the ruling and continued to develop seven artificial islands in the South China Sea's Spratly archipelago. During the last 8 years of the Obama administration, United States had carried out 6 FONOPs from 2013 to 2016.
Syria's six-year-long civil war has killed at least 400,000 people with half of the country's population having fled their homes, according to the UN.
The Syrian Observatory for Human Rights, a UK-based monitoring group, reported that the powerful blast believed to be located near the main road leading to Damascus International Airport, was heard across the capital at dawn on Thursday.
In September of last year, Ottolenghi observed, "Flight records show that Iran Air's flight 697 - the Tehran-Damascus route - was operated 66 times over the last year, including three times from Abadan, on Sept. 8, June 9 and May 10". Hezbollah fired more than 4,000 rockets on Israel in the 2006 war.
The Syrian army said on January 13, 2016 that Israel had targeted the Mezze military airbase.
In the region nearest to Israel, Hezbollah and its government allies are fighting anti-Assad forces led by an al-Qaeda linked extremist group.
Hezbollah is a Lebanese militant group and political party, funded and supplied by Iran.
Yahya, the analyst, said Israel is increasingly anxious about the potential arsenal that Hezbollah's could acquire and the weapons already available in Syria.
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