Syria has been locked in a vicious civil war since early 2011, when the Assad regime cracked down on pro-democracy protests - which erupted as part of the Arab Spring uprisings - with unexpected ferocity.
The US attack on a Syrian air base Thursday devastated an airfield, sent a stark message to Syria and its protector Russian Federation and raised a host of questions about whether and how the Trump administration's stance on the Middle East might change.
"We are prepared to do more but we hope that will not be necessary", she said, adding that the "world is waiting for Russian Federation to act responsibly".
At least 80 civilians died in the air attack on the town in rebel-held Idlib province prompting an worldwide outcry.
Thursday night's strikes - some 60 cruise missiles fired from two ships in the Mediterranean - were the culmination of a rapid, three-day transformation for Trump, who has long opposed deeper United States involvement in Syria's civil war.
The official Saudi Press Agency is reporting that U.S. President Donald Trump has spoken by telephone with King Salman about the U.S. missile strike on Syria. "We strongly condemn the illegitimate actions by the US The consequences of this for regional and global stability could be extremely serious", Russia's deputy UN envoy, Vladimir Safronkov, told a meeting of the UN Security Council on Friday.
Media captionWATCH: What is Trump's plan in Syria? "We support the United States in that swift action". Why they are supporting a regime that is committing mass murder against its own people.
"I find it very disappointing, but sadly, I have to tell you, not all that surprising", he said.
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As US allies in the Middle East, Europe and across the world lined up to commend the US action, Taoiseach Enda Kenny said that the issue was a "matter of grave concern", noting that the US government had given warnings to those in the vicinity of the targeted area before the attack, and adding that he believed the use of chemical weapons was a war crime.
"We are carefully assessing any information that would implicate the Russians knew or assisted with this capability", he said. "There is no solution from America, all that comes from America is chaos and blood", he said.
UN Secretary General Antonio Guterres urged restraint and a renewed push for peace in Syria, saying "there is no other way to solve the conflict than through a political solution".
At the United Nations on Friday, Russia's deputy ambassador, Vladimir Safronkov, strongly criticized what he called the USA "flagrant violation of worldwide law and an act of aggression" whose "consequences for regional and global security could be extremely serious".
Trump announced the strike in a brief televised address. "Regime change is something that we think is going to happen because all of the parties are going to see that Assad is not the leader that needs to be taking place for Syria".
Russian Prime Minister Medvedev warned on Friday that the immensely reckless action had brought Washington to "the verge of a military clash" with nuclear-armed Russia, which had an air unit at the base struck by American missiles.
Putin spokesman Dmitry Peskov's remarks came two days after the suspected chemical attack killed at least 72 people.
The impact of the strikes was also unclear.
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