The bomb, known officially as a GBU-43B, or massive ordnance air blast weapon, unleashes 11 tons of explosives.
Afghan officials have ruled out civilian casualties in the bombing.
The site where the "mother of all bombs" was dropped on an ISIS complex in Afghanistan.
On Thursday evening, the USA military dropped a GBU-43 or Massive Ordnance Air Blast (MOAB) bomb, the largest non-nuclear bomb, on an IS cave complex in Achin District, Nangahar Province bordering Pakistan.
US President Donald Trump called the bombing "another successful job".
The U.S. estimates that between 600 to 800 ISIS fighters are present in Afghanistan, mostly in Nangarhar.
Karzi said, "I vehemently and in strongest words condemn the dropping of the latest weapon".
But the group has been steadily losing territory in the face of heavy pressure both from USA air strikes and a ground offensive led by Afghan forces. The target was close to the Pakistani border.
Mr Crowley, a former U.S. air force colonel, said the bomb was "like creating a minor quake in that particular area".
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A separate non-nuclear weapon known as the Massive Ordnance Penetrator, or MOP, which is larger in its physical dimensions but carries a smaller load of conventional explosives, is created to take out deeply buried targets like reinforced bunkers. This munition was developed during the Iraq War.
U.S. army general John Nicholson, the commander of American forces in the country, said IS - also known as ISIS-K in Afghanistan - were using improvised bombs, bunkers and tunnels to "thicken their defence", so the massive bomb was a necessary response.
The commander of USA forces in Afghanistan, Gen. John Nicholson, said in a statement Thursday that it was the "right munition" to use to destroy the militants' network of tunnels in the area.
Adam Stump, a Pentagon spokesman, said the bomb was dropped from a U.S. MC-130 special operations transport.
District governor Ismail Shinwari said there is no civilian property near the air strike location.
The strike came just days after a Green Beret was killed fighting ISIS in Nangarhar, however, a USA defense official told Fox News the bombing had nothing to do with that casualty.
One man, who did not want to give his name for fear of ISIS retaliation, said there were no civilians left in the area the group controlled.
In a message distributed on the instant messaging app Viber, the Taliban said the United States had "no justification" for using such a powerful bomb during combat operations, calling it a "show" by US forces to persuade the world it is battling the Islamic State.
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