City, who have won their last eight Premier League games on the trot, but suffered a disappointing midweek Champions League first-leg loss to Tottenham, could significantly add to the pressure on Liverpool to beat Chelsea at Anfield if they win.
Three days before a potentially season-defining Champions League quarterfinal second leg against Tottenham, with Guardiola's men trailing 1-0 in the tie, City were able to keep the title race in their own hands without going through the gears. Sometimes you miss, you have to forget about it and go for the next one. "The finishing from Sterling was incredible".
City are looking to become the first side to retain the title since Manchester United achieved the feat in 2009, whilst Liverpool are seeking a first top-flight title in nearly three decades.
"When I was younger you always want to score your first opportunity and sometimes it doesn't happen like that", he said.
Despite that scare, City wrapped up in the win in the 90th minute as De Bruyne launched a counter and set up substitute Gabriel Jesus (who looked to be just offside) to slot home the third.
Charles Leclerc slams "stupid" qualifying error for Chinese GP
Verstappen was still furious at Vettel in his post-qualifying interview. From now on in qualifying, I'm going to f*** them up as well".
That game kicks-off just minutes after the final whistle at Selhurst Park, making it all the more vital that City land a psychological blow by going back to the top of the table against Palace.
But Palace showed a flicker of attacking life soon afterwards, Milivojevic crossing and Christian Benteke heading down before City hacked clear.
Leroy Sane then dribbled at goal and forced Vicente Guaita into a smart stop at his near post and Aguero smashed a shot over the bar.
City started brightly and had a big chance to take the lead, with David Silva wriggling away from defenders inside the box and then setting up Sterling who somehow dragged his effort wide.
Last season, Palace ended City's record 18-game winning run last season but Guardiola's team still amassed 100 points as they cruised to the title.