The accident happened at about 2 p.m. PT on Sunday when the plane, a twin-engine Cessna 414A, went down in Yorba Linda, a city about 26 miles (42 kilometers) southeast of downtown Los Angeles.
Two houses were involved in flames, fire officials told KTLA.
Two people died and two others were injured when a small aircraft crashed into a residential area in Yorba Linda, California.
The Cessna 414A had just departed from nearby Fullerton Municipal Airport before the crash, according to Allen Kenitzer, a spokesman with Federal Aviation Administration.
Twitter user Joshua Nelson wrote, "A few houses down [from the crash] the propeller and engine landed in their yard".
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Anaheim firefighters and deputies from the Orange County Sheriff's Department helped respond to the fires.
Authorities say a small plane has crashed in a suburban Southern California neighborhood and has ignited a fire that burned two houses.
The number of people in the plane are unknown.
Footage from the scene shows that multiple homes were damaged, one of which was fully engulfed in flames.
This is a breaking news story and is constantly being updated.