The Terriers head into the clash as heavy underdogs, but Wagner hopes they can physically impose themselves against Unai Emery's side, who have gone 20 games unbeaten across all competitions.
Arsenal defender Rob Holding is set to miss the rest of the season after the Premier League club on Friday announced he had sustained cruciate ligament damage.
The head coach stated that Ozil will be a game-time decision.
After Mark Hughes was sacked, Mourinho is now the Premier League manager most at risk of the sack and Metro report that Mauricio Pochettino is far and away Ed Woodward's top choice to replace him.
However, his first spell at Chelsea, between July 2004 and September 2007, is the only time in his managerial career he has stayed longer than three seasons at a club.
Diogo Dalot: Manchester United hosting Fulham a 'big game' after winless run
It was an enjoyable summer and a good season for me on a personal level last season. We started off very well and I thought we probably did deserve more than the draw.
"He's working with us every day in training and playing in the Under-23s with good feeling".
"We also have to be more brutal in one or another situation to make sure we show everybody that we fight to keep the ball out of the net".
Hector Bellerin is expected to be the right-back once again, while Sead Kolasinac should continue on the opposite flank.
Manchester United defender Diogo Dalot is confident that his side can still finish in the top four this season despite now sitting six points behind Chelsea and Arsenal.
As iterated earlier, Xhaka is available after his suspension and should partner Lucas Torreira in the midfield pivot, meaning Matteo Guendouzi will have to settle for a place on the Arsenal bench. He played 85 minutes on Tuesday and our plan is that he can maybe be with us in the 18 on Saturday. In fact we may even start keeping a few more clean sheets with Koscielny leading from the back....