"I think the circumstances of the past year, I think the club is not only focused on winning titles or winning games", the former Espanyol and Southampton boss said.
"If you are going to assess how West Ham are going to arrive, they going to play Saturday and then Wednesday against us but we play Wednesday, Monday and then Wednesday and we are not going to arrive in a similar condition".
Given Mauricio Pochettino's willingness to put his faith in young talents when required and with few options available to him after a summer without any signings, Roles could be closing in on a first team debut.
The Premier League champions will travel to Wembley for their next assignment in the league against Tottenham in what promises to be an entertaining clash on Monday night.
Pep said: "We sing with the staff, every time we go out we always sing this song together".
But Tottenham remain well in the hunt for the Premier League title, sitting just two points adrift of City after nine matches.
And Guardiola believes Spurs have suffered for playing away from their traditional home since the beginning of last season, recalling a 2-0 defeat at the old stadium in north London early in his City tenure.
"City boss Pep Guardiola said his side's performance in their midweek win over Shakhtar Donetsk was the best he had seen since he has been at the club, so it would appear they are in decent form too".
Extended Brexit transition period not a problem
A source told The Sun : 'There is no orchestrated campaign to remove her but there is mounting dissatisfaction in every quarter. Labour has said that "all options are on the table" if they do not like the deal Mrs May comes back with.
Groundsmen have begun work on doing their best to fix it in time for the Premier League match, but there is only so much they can do - they are not magicians.
Of course City deserve to be favourites and no-one will be in the least bit surprised if they win the game, but a relatively full-strength Spurs side - should Alli and Eriksen start - will present plenty of problems of their own.
In mid-August, matches against Liverpool and Cardiff were moved, and Tottenham announced in early September its match against October 29 game against Manchester City and all three Champions League group stage matches would be at the national stadium. "To be loved. The most nice thing is when you feel good with the other people".
"I remember in that period people were saying City is going to win the Premier League". We are lucky to have a squad with huge quality.
He said: "All the players want to play good, be ready, be part of the team".
"But the club needs to be all focused in trying to win titles".
'I don't believe that in football you can find something that is impossible to do, but it will be hard of course because we need to play well and perform at our best, have a bit of luck to win the game'.
Tottenham will continue to host matches at Wembley Stadium until at least the end of the year as the opening date of their new home venue remains a mystery.