According to People, only 20 family members were in attendance at the low-key ceremony, held at the Bush family's compound in Kennebunkport, Maine.
George W. and Laura Bush and former President George H.W. Bush were all at the wedding.
The wedding ceremony was a true family affair, with the bride's aunt Dorothy Bush Koch officiating.
The bride's twin sister, Jenna, wrote in an emotional post on Instagram, "Happy tears, heart exploding as I watched this handsome girl get married in the place that means love and family".
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But perhaps more important is how much fun she is having with it. "(And I've rarely had a hard time with accents)". Naturally, she also comes with her distinctive sonic screwdriver, because ... well, why wouldn't she.
The couple met on a blind date a year ago and got engaged over the summer, People reported. "And we've been long-distance for most of it - he's been in L.A. and I've been in NY - but we've gotten to spend a lot of time together".
Craig Coyne, a 37-year-old screenwriter from Atlanta, has appeared in several films and shows, perhaps most notably the feature hit "Jarhead."
The bride, who serves as the co-founder and chair of Global Health Corps, a non-profit that supports emerging health professionals, wore an ivory silk crepe Vera Wang custom gown, according to the statement.
Bush honored her late grandmother and namesake, former first lady Barbara Bush, by wearing one of her bracelets.
The bridegroom, a native of Georgia and graduate of Vanderbilt University, is a screenwriter.
Laura had a family-only wedding at the family's Kennebunkport, Maine, home, and was surrounded by her nearest and dearest including her parents and twin sister, Jenna Bush Hager.