The 23-year-old sent in an exceptional pass for Marcus Rashford's opener on his first worldwide start since September 2015 - an appearance that came just a week before the disgusting injury that he recently revealed almost cost him his leg.
Shaw had started United's first four games of the season, which included him scoring against Leicester in the opening fixture, and he was named in the starting lineup against Spain.
Rashford's opener, following an 11th-minute Luke Shaw cross, hinted at a performance and result that would extend the team's post-Russia honeymoon period.
Substitute Danny Welbeck saw a stoppage-time leveller controversially ruled out, meaning England head into Tuesday's friendly against Switzerland reeling from three successive defeats in all competitions for the first time since 1988.
The Manchester United left-back took to Twitter to reassure England fans of his condition following the game.
UEFA is yet to use video assistant referees in its competitions despite the new technology's successful deployment for the first time at the World Cup.
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Following a hard first season at Old Trafford, he was in fine form during the first few weeks of the 2015/16 season before having his leg broken by PSV Eindhoven's Hector Moreno in the Champions League.
Physios attended to the injury for more than five minutes before the Manchester United player was carried off on a stretcher.
"I was really close to losing my leg".
The extent of Shaw's injury is not yet known.
The hosts did nearly get one back soon after, only for Rashford to be denied by a superb save from David Gea.
England raised the tempo when they got on the ball although the visitors' passing and movement off the ball had the home side on the backfoot.