Trump traveled to a high school north of Columbus for a political rally Saturday night.
It took the Tweeter-in-Chief nearly a full week to respond.
Trump happened to see the interview on Friday, and the president blasted both James and Lemon in a tweet posted just before midnight.
A number of athletes jumped in to defend James. The I Promise School opened its doors Monday in Akron, Ohio ― LeBron's hometown ― and has won praise from advocates for public education like Diane Ravitch.
While NBA athletes, entertainers and politicians alike fired off a flurry of responses directed at the president, James' first tweet following Trump's diss made no mention of the former reality TV star turned politician.
"It looks like LeBron James is working to do good things on behalf of our next generation", she said.
The statement noted that Mrs. Trump has been promoting her Be Best campaign and talking to children about the "importance of responsible online behavior".
During the interview, James and Lemon toured the school and discussed sports, politics and race relations.
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Minnesota Timberwolves power forward Anthony Tolliver called the president's statements an "embarrassment".
His biography on the official NBA website reads, "By acclamation, Michael Jordan is the greatest basketball player of all time".
His comment sparked a huge reaction from James' supporters - but the most surprising came from First Lady Melania Trump, whose communications director issued a statement that appeared to break ranks with the president. "He's doing an unbelievable job for his community", Jordan said through a spokeswoman.
"The network's communications team responded to Trump's tweet, suggesting that if Trump was watching CNN, it must have been because first lady Melania Trump was choosing the channel", the Hill reported. James has always been an outspoken critic of the Trump administration, as well as a political activist and philanthropist. James also said that he'd "never" sit down for a meeting with Trump.
This weekend's controversy was just the latest in a long-running feud between James and the president.
Trump's wife First Lady Melania Trump, however, doesn't seem to be on the same page about James.
When it comes to his school, James is focused on shaping the minds who will change the world.