Maryam Nawaz tweeted a photo of her hugging her distraught daughter and son before leaving for her flight, with the caption: "Goodbyes are hard, even for the grown-ups".
They have been been convicted in the Avenfield corruption case.
Sharif said that "draconian crackdown" on his supporters by the Punjab government shows that the authorities are scared of his appeal and are desperate to stop tens of thousands of people from reaching Lahore airport to welcome him and his daughter. They would be kept at Adiala jail for 1 day and then would be transferred to Attock Fort. But I'm doing this for people of Pak, sacrificing for generations to come.
The Cabinet Division has reportedly allocated two helicopters - reserved for the prime minister - to NAB to shift Sharif and his daughter to the jail from the airport.
Sources said Nawaz Sharif and Maryam are fully cooperated with the 16-member NAB team.
Nawaz Sharif was also fined eight million and Maryam Nawaz two million pounds.
Clashes broke out Friday evening at the main highway entry point to Lahore between pro-Sharif protesters and police who had been deployed in their thousands, a Reuters witness said.
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They are set to be arrested after their arrival here from London following their conviction in a corruption case described by Pakistan's embattled former prime minister as a "blind revenge" amid a crackdown on his party activists.
A spokesman for Sharif's Pakistan Muslim League-Nawaz (PML-N) party confirmed they were arrested soon afterwards. I am aware that I have been sentenced to 10 years (in prison) and I will be taken to a jail cell straight away.
PML-N leaders claimed that around 300 workers were arrested from Rawalpindi on Tuesday, while several hundred others had been picked up from Lahore and other cities.
Urging the Election Commission of Pakistan (ECP) to take notice of the emerging situation, the PML-N president said, "By the time our workers are released polls will be over".
Their return could shake up an election race marred by accusations Pakistan's powerful military is working behind the scenes to skew the contest in favor of ex-cricket hero Imran Khan, who describes Sharif as a "criminal" who deserves no support.
Shahbaz Sharif is expected to lead a rally to Lahore's Allama Iqbal International Airport to receive Nawaz Sharif and his daughter.