That set up the flawless chance to give Toure a fitting send-off - the veteran making way to a standing ovation as City moved one win away from claiming 100 points.
Chelsea lost a third record on Wednesday night as City eclipsed their points tally from the 2004/05 campaign (93).
"We have to be careful".
"We want 100 points and finish this almost-perfect season in the Premier League", Guardiola said.
A surprisingly much-changed Chelsea side from the one that beat Liverpool four days ago fell behind when Laurent Depoitre forced the ball home five minutes into the second-half.
Making his first league start of the season, Toure turned on the style with a clever cutback to Gabriel Jesus as City looked to restore their lead, only for the striker to slice wide.
Guardiola said he agreed with those who argue that City need to win more titles to be considered the equals of the great sides of the past, including Liverpool and Manchester United.
Potential 'cure' for baldness found in side effect of osteoporosis drug
The lack of treatment for the hereditary condition has led to thousands of men undergo painful hair transplant procedures. Follicles soon went into the active phase of hair growth - known as "anagen" - and began sprouting new hair.
As Chelsea's records were falling, they were also struggling to get the better of Huddersfield at Stamford Bridge. Yet that season was over 42 games not 38 so, by any yardstick, City have been truly exceptional.
'They have been educated like that because they are champions.
"Well, at this moment we're not relegated", he shrugged.
"To be the best we have to win more".
Pep Guardiola is set to name his strongest possible line-up for Manchester City's final game against Southampton at St Mary's. Manchester is their town.
Now safe, Dave Wagner's men will be looking to send Arsene Wenger off into the Premier League sunset without the farewell win his 22 years at Arsenal surely demand.