Nolan Arenado charges Padres' Luis Perdomo after message pitch

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All hell broke loose in the third inning (the third inning?) of Wednesday afternoon's Padres-Rockies game at Coors Field.

San Diego bench coach Mark McGwire, along with the Rockies' Carlos Gonzalez, tried calming Arenado down.

The Colorado Rockies lost to the San Diego Padres Tuesday night, which guaranteed a second consecutive series loss for the club and a losing record on their first homestand of the season. In the bottom of the first inning of Wednesday's game, Perdomo hit Trevor Story with a 1-1 fastball.

Tensions started bubbling between the two teams Tuesday when Scott Oberg hit Padres outfielder Manuel Margot with a pitch in the ribs, which sent him to the 10-day disabled list on Wednesday.

Lucchesi's line stayed there because Kazuhisa Makita retired Ian Desmond (flyout), Gerardo Parra (strikeout) and Pat Valaika (foul out) in order to end the threat.

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Colorado broke open the game after the melee, sending nine hitters to the plate with most of the damage off reliever Buddy Baumann when he took over for Perdomo. The big play was Tony Wolters' bases-loaded, two-run single that center fielder Franchy Cordero misplayed to allow another run to score.

The Padres roared back for three runs in the sixth off of right-hander Antonio Senzatela, who had replaced Marquez.

Antonio Senzatela (1-1) struggled over three innings while filling in for Marquez.

Rockies: CF Charlie Blackmon was scratched from the lineup with tightness in his right quad. The Padres have not swept a series in Denver since 2011. RHP Bryan Mitchell (0-1, 4.22 ERA) goes for San Diego.