This marks the 38th appearance all-time appearance for the Wildcats in the NCAA Tournament and fourth time they have earned the No. 1 seed.
Villanova, Kansas and Xavier joined Virginia as the top seeds.
The No. 5-seeded Cats will take on A10 Champions, the No. 12-seeded Davidson Wildcats in Boise, Idaho in the tournament's South Region.
The Wildcats have played LIU Brooklyn once and never have seen the Radford Highlanders in program history.
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The Boilers and Bulldogs are officially headed to the NCAA Tournament.
Two years ago, Villanova came out on top of one of the most awesome championship games in the big tournament when Kris Jenkins hit the game-winning shot from beyond the arc to give the team their first title since 1985.
The four teams advancing to the regional semifinals will meet at the CenturyLink Center in Omaha on March 23. This is the third time in the last five years that the Cavaliers have been selected as a number one seed.