"Periods of heavy snow will arrive into Friday across the southern Great Lakes", said weather.com meteorologist Jonathan Belles.
Anyone who needed to travel Friday morning should allow for extra time, the service stated.
The storms could leave more than a foot of snow in some parts of Chicago area by Sunday, according to the report.
Road travelers should also check weather updates, exercise caution and leave themselves plenty of extra travel time if staying put isn't an option as several inches of snow are expected in a large zone stretching from Montana to ME through Friday night.
Schools in Chicago and MI announced cancellations ahead of Winter Storm Mateo.
A spokesman for Edward Hospital in the Chicago suburb of Naperville says a man in his 60s suffered a fatal heart attack Friday morning while shoveling snow.
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By early Friday, more than 100 flights were canceled at Detroit Metropolitan Airport in Romulus, Michigan.
Schools and travel saw major impacts across the Midwest on Friday as Winter Storm Mateo dumped inches of snow across a large section of the nation's heartland. If the storm shifts north, the amounts will be higher and if it moves south, they will be lower.
Rachel Linn shared a photo of a tranquil snow-covered street early Friday. Expect sloppy road conditions heading to work Friday.
The National Weather Service issued winter-weather warnings and advisories across the upper Midwest.
The city of Marshall will be under a snow emergency from 9 p.m. tonight until 6 a.m. Saturday, city officials announced this afternoon. Snow accumulating 3 to 5 inches.