Thursday Night Football covets the No. 2 spot in prime time, as well.
NFL Network will also air seven games exclusively, which will be produced by Fox.
According to early reports, FOX is hoping a news and sports focus would help them as the world of pay-TV is changing.
Fox is getting the NFL's Thursday Night Football package for the next five years.
FOX will distribute its Thursday Night Football and Sunday games to subscribers via numerous digital platforms, including mobile phones.
Fox agreed last month to sell cable channels FX and National Geographic, its movie and TV studio and global assets to Disney. According to Darren Rovell of ESPN, the deal is pegged at an average of more than $660 million per year. In the past, the National Football League has partnered with Twitter and Amazon for those rights.
The NFL has broadcast Thursday Night Football for the past 10 seasons. CBS and NBC reportedly submitted bids lower than the value of the current deals.
The NFL created the Thursday night package in 2014, and for each of the past three seasons the right were sold on a year-by-year basis.
"These opportunities come along very, very infrequently", Peter Rice, 21st Century Fox president, told A.P.
Guess who saved the NFL and friends, ensuring all that the knee-taking - not to mention the other issues fans complain about - didn't kick the league and its players in the bottom line? Calling TNF would give Johnson and Klatt the rare Thursday/Saturday night double, and would certainly raise their profile, but would having the duo split their attention between the NFL and college football diminish their quality?