Now unbeaten in their last eight Premier League appearances, Roy Hodgson's revitalized Crystal Palace side will be aiming to cause a dent in Arsenal's top four hopes. Now sat sixth in the table, the Gunners are four points adrift of the top four, they're also three points behind arch-rivals Tottenham.
Arsenal were booed off at Selhurst Park last season as they lost 3-0 and saw their European aspirations dissipate amidst away supporters singing 'You're not fit to wear the shirt'.
Arsenal played out a 3-3 draw against Liverpool last week.
Nacho Monreal has been ruled out after sustaining an inury against Liverpool, while Olivier Giroud and Aaron Ramsey are also sidelined.
Spanish midfield maestro Santi Cazorla remains a long-term absentee with an Achilles injury. My old team-mates at Schalke played their last game of the year on the day we beat West Ham in the cup, so they are on holiday now.
Now sat 16th in the table, Palace are still only a single point above the drop zone and know they're still not out of the woods.
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They often outplayed their hosts, securing victory when a finish from Shkodran Mustafi and two goals from Alexis Sanchez ensured they remain sixth and continue their push for the top four, but were also frequently stretched.
Manchester United loanee Timothy Fosu-Mensah may be available once again after a recent hamstring complaint, whilst Christian Benteke is back again after serving a one game ban.
Hodgson still finds himself without Mamadou Sakho whilst the Frenchman recovers from a calf injury, and will also be without Damien Delaney and Connor Wickham for the London derby.
Arsenal have only won two Premier League away games this season - their joint-fewest tally after nine away games of a campaign in the Premier League era.
Discouragingly for Wenger, amid Palace's pressure and obvious ambitions, they scored another late goal his team did little to resist.