NPR's Diaa Hadid, reporting from Islamabad, notes that the attack comes just one week after ISIS stormed a different security compound in Kabul. The authorities have confirmed the casualties in the attack. "Since then it has targeted security forces, eroding their already low morale", Dia says.
Officials said another five people were injured when the attacker, who was on foot, blew himself up as agency employees were on their way to work.
Najib Danish, spokesman for the Interior Ministry, said three other people were wounded in the attack, adding that the exact target was unclear.
Qari Yusouf Ahmadi, a Taliban spokesman, claimed responsibility for the attack in Helmand.
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A teenage suicide bomber staged Monday's attack near the entrance of the spy agency's headquarters in Kabul's Green Zone diplomatic quarter, according to the Afghan interior ministry.
On December 18, iS claimed responsibility for an attack on the intelligence agency's training center in Kabul.
The assault came to an end after forces successfully killed two attackers.