Tottenham failed to pick up scorer Ilkay Gundogan for City's opener and, after Kevin de Bruyne made it 2-0 in the 70th minute, conceded two late goals to Raheem Sterling as they pushed bodies forward, Christian Eriksen's late consolation rendered meaningless.
Guardiola hailed his side in the wake of the result, saying his talented squad continues to knuckle down despite their 16 match top flight winning run.
"I think it was a good experience for the team, when you win and play well you maybe don't learn, so you must learn from this type of game", he told BBC Sport.
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"It's true that the team in front was better than us, but now it's about trying to lift our players for the next game, because now this game is in the past".
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"Without the ball we are a humble team". You can not imagine how well he plays with the ball, but you also see how he runs.
"Since August we are so happy and I admire the most the way we play without the ball - thank you to the club to provide me with these unbelievable players". Today was a very good example to see a team that believes, that has a lot of quality and strength, and is in very good form.
"When you play against teams like Manchester City, if you concede after 14 minutes a goal like this - come on - we can not assess individual performances".
"He gives us the chance to show others how one of the best players runs like a player in the Conference, and when this happens it's easier for the manager of the club". The bad news was that there was a guy from Belgium also playing that none of Tottenham's England contingent, or team as a whole for that matter, had much of an idea about how to stop. We must learn, because one day we want to be in a position to win the Premier League, but today was a big lesson for us.
City will retain their lead over second-placed Manchester United if Jose Mourinho's side lose to West Brom on Sunday.