Long-term absentees Toby Alderweireld and Victor Wanyama remain sidelined.
Brighton generally have a clean bill of health, apart from midfielder Steve Sidwell, who has a problem with his lower back.
Winger Anthony Knockaert could be recalled after being left out of the side that was beaten by Huddersfield at the weekend.
Having got back to winning ways, Tottenham are fully expected to carry that momentum forward. Four points up, a draw here will taste like a win. "They are a very good team with very, very good players". Probably not because whatever points you have, you have to earn them. I agree with Mr Allegri, we must always be positive. "But in this division, your next game could be a very hard one and you've got to show you accept what the division is, have learned from it and do your best in the next game".
Think you can do better than Lawro?
Juventus have been eliminated in their last five appearances against English competition.
It's a decade since the former Spurs coach was relieved of his duties at the same time as then-manager Martin Jol, but he is still highly regarded in north London - not least because he has steered Brighton to a respectable 13th in the Premier League table. Mauricio Pochettino's men defeated both the sides and finished as the side with the most number of points in the group stages of the competition.
Iran natural disaster : Magnitude 6.2 quake jolts Kerman province
The first quake of magnitude 5.9 struck on Tuesday morning 56 km north of Kerman, a city with a population of more than 820,000. On November 12, in one of the deadliest earthquakes, a magnitude 7.3 quake struck the border region between Iraq and Iran.
Juventus vice-president Pavel Nedved insists they have nothing to fear facing Tottenham in their Champions League tie.
"We had a tough spell in the Premier League recently and we wanted to put that right", said Kane.
A midfield engine room containing Erik Dier, Mousa Dembele and Victor Wanyama, who has missed a large portion of the season so far through injury, means the Old Lady are likely to have to do a lot of running if they are to match their unsafe opponents.
Brighton have failed to win on their three previous trips to Wembley - losing the FA Cup final to Manchester United 4-0 in a replay after a 2-2 draw, and losing the 1991 second tier play-off final 3-1 against Notts County.
Probability of away win: 7%.
They have conceded seven goals from corners, a league high.