In Italy, he scored 15 goals and made 11 others as he helped Roma finish second in Serie A, their best league placing in seven years, prior to joining Liverpool and scoring 13 times in his first 16 league games. Keita, who is set to join Mane and Salah at Liverpool this summer and will replace Salah as Liverpool's most expensive player ever, finished fifth.
Liverpool and Senegal winger Sadio Mane is another in with a big chance.
Gabon's Borussia Dortmund striker Pierre-Emerick Aubameyang, Guinean Naby Keita - his future Liverpool team-mate now at RB Leipzig - fellow Reds star Sadio Mane of Senegal and Chelsea's Nigerian winger Victor Moses lost out to the pacy attacker, nicknamed the "Egyptian Messi".
After receiving the award, he told BBC SPORT: "I'm very happy to win this award, it's a special feeling for me". I would also like to win it next year! I had a very good start with the team, and also the manager [Jurgen Klopp].
The Liverpool wideman is also in contention for the CAF Player of the Year award, in which the victor will be revealed in January.
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Salah accomplished what his predecessors, Mohamed Barakat in 2005 and Mohamed Abou-Treika in 2008, achieved and became the third Egyptian player to conquer the award.
"I have always followed my way, and I want everyone in Egypt to follow my way".
'Since I left Egypt, in my mind, I want to be the best Egyptian ever. "I work hard and try to be different from them".
'It's well deserved, ' said Reds boss Jurgen Klopp.
'The good thing is that he is still young, there is a lot of space for improvement, a lot of potential still that we can work on, but that's how it should be.