Playing fictional character Jake Byrd, comic Tony Barbieri wore a shirt that read "Gimme Moore" while interrupting Moore's speech to shout that the ex-judge is a "man's man", and asking if the Senate candidate's mug looks "like the face of a molester".
Perhaps as a tactic to rile up support among his deeply conservative base while these allegations swirl around him, Moore has chose to pick a fight with that most reliable breed of boogeymen: a late-night talk show host.
Moore is now firing back.
Taking issue with the stunt, Moore angrily tweeted at Kimmel, "If you want to mock our Christian values, come down here to Alabama and do it man to man".
The move comes amid controversy surrounding the Republican candidate, Roy Moore, who has been accused by several women of pursuing inappropriate sexual relationships with them when they were between 14 and 19 and he was in his early 30s.
"Sounds great Roy - let me know when you get some Christian values and I'll be there!"
Moore responded with an invitation.
Tony Barbieri in character as Jake Byrd went to one of the would-be Senator's rallies to give him faux-support while actually pointing out his flaws
"This most recent incident is about Moore deflecting blame by placing it on one of his favorite targets: our community".
Decades-old accusations involving young women are now threatening Moore's political life in a race against Democrat Doug Jones. "They've tried unsuccessfully to change that".
On Wednesday, Moore doubled down on proclaiming his innocence.
During his campaign, Moore has called on Congress to impeach the federal judge who blocked President Donald Trump's ban on transgender troops and to boot from the bench the Supreme Court justices who found in Obergefell that gay and lesbian couples have a constitutional right to marry.
Moore also went on to claim that "drugs were at the base" of the allegations against him.
Moore, who faces off against Democrat Doug Jones on December 12, did not immediately respond to NBC News' request for comment.
Alabama voters go to the polls on December 12 to replace Jeff Sessions, who is now the United States attorney general.
How to watch the only visible "supermoon" of 2017 this weekend
Perigee defines the closest point in the moon's orbit around the Earth , and the Supermoon will reach this spot at 3:45 a.m. In 2016 the moon was the closest its been to the Earth since 1984 and that distance won't be challenged again until 2034.