The Spurs won the first game in the season series by a count of 108-101 on their home floor on November 3.
Walker was held to 13 points on 4-of-12 shooting in the loss at San Antonio but has averaged 17.6 points and 4.3 assists in 11 games against the Spurs.
With All-NBA forward Kawhi Leonard and veteran point guard Tony Parker still rehabbing quad injuries that have sidelined them for months now, the Spurs' backups have had to step up and see considerable action since the start of the season. Charlotte was outscored 46-42 in the second half.
The Cavs beat the Hornets 115-107 on November 15.
LeBron James recorded the 57th triple-double of his career Friday night in Cleveland's 100-99 win over the Charlotte Hornets to extend their season-long win streak to seven games. Rudy Gay scored a team-high, 19 points, during their last game against the Pelicans. We had turnovers and did not move the ball as well, so they were able to take advantage of that.
Theresa May hails resignation of Zimbabwean leader Robert Mugabe
The 93-year-old had led the African country for 37 years, but resigned as impeachment proceedings began against him. That decision was seen by many as clearing the way for Mr Mugabe's wife, Grace, to succeed her husband as leader.
Trail Blazers 127, Nets 125: Damian Lillard scored 34 points, Jusuf Nurkic added 29, and visiting Portland rallied from a six-point deficit late in the fourth quarter.
San Antonio shot 39.8 percent overall (35/88) and 25 percent (6/24) from the three-point line in the loss to New Orleans.
Charlotte will play San Antonio on the second night of a back-to-back.
San Antonio is 2-5-1 in its last eight meetings in Charlotte.
Howard, who totaled 20 points and 13 rebounds Friday, is averaging 15.5 points and 12.9 rebounds in his first season with Charlotte. Jeremy Lamb missed a 3-pointer after the Hornets inbounded at midcourt and the rebound was tapped out to Kemba Walker, but his 3-point attempt fell well short after James got a hand on the shot. He returned to play in five games, but suffered a setback on November 7 and has not played since.