Ortiz booted, Wilder-Stiverne II to take place on November 4

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Wilder toppled Stiverne in 2015 to earn the WBC heavyweight title and is the only opponent the heavy-handed Alabama native has failed to knockout. Since that loss, Stiverne has fought only once, a much tougher than expected decision win against journeyman Derric Rossy, who knocked him down in the November 2015 bout, though Stiverne had a title eliminator against Povetkin scheduled for December that was canceled when Povetkin again failed a random pre-fight VADA test.

The WBC said in a statement: "The WBC has concluded the process according to its Clean Boxing Program protocol in the adverse finding of Luis Ortiz".

Ortiz, a 38-year-old Cuban, was found to have used chlorothiazide and hydrochlorothiazide, both banned substances that are often used to mask performance-enhancing drug use.

Breazeale is, for all intents and purposes, out of the November 4 card and promoter Eddie Hearn is now trying to book a fight between Stiverne and Dillian Whyte to be done at the Anthony Joshua vs. Kubrat Pulev undercard on October 28. It was the only career non-knockout for Wilder, who is 38-0 with 37 KOs.

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'In the first fight, I broke my hand in the third round, and I still dominated.

Stiverne, 39, remains the only fighter to go the distance with "The Bronze Bomber" in 38 bouts, but has fought just once since the reverse and has been out of the ring for nearly two years.

But Wilder will still start the fight as an overwhelming favourite to record his sixth successful title defence. "Considering Stiverne's status as mandatory challenger, he was always going to be a roadblock in Deontay's quest for heavyweight unification".