Sproles, a three-time Pro Bowler, rushed for 61 yards this season on 15 carries.
Sproles' torn ACL will end his season, and possibly his career, unless he changes his mind about retiring.
Sources told ESPN that Sproles will have surgery on his arm on Monday.
Coming back from a broken arm isn't a problem for an National Football League player at any age, but a torn ACL is tougher.
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He had said coming into the year that this will probably be his last season.
Two-time Pro Bowl defensive tackle Fletcher Cox (calf) and starting linebacker Jordan Hicks (ankle) also were injured against NY.
Off the field, the Eagles will be losing one of the most respected players in the locker room.
Had Sproles remained healthy in 2017 he'd have an opportunity to eclipse the likes of Steve Smith, Marshall Faulk, and Tim Brown for fifth all-time. Blount is the best bet for touchdowns from that group, but Smallwood is best suited to take on Sproles' former role.
Should Sproles reach Canton, he'd be the shortest inductee in the Hall of Fame's history.