The Patriots scored 30 points in the first half, taking a 17-point lead to the locker room.
Brady's first-quarter scores were a 19-yarder to running back Rex Burkhead, a 53-yarder to tight end Rob Gronkowski and a 13-yard pass to Chris Hogan. Brady was ineffective and often off-target, completing 16-of-36 passes (44 percent) for 267 yards with no touchdowns.
Tight end Coby Fleener showed signs of becoming the fauture face of the New Orleans' offense after an wonderful performance in the game 1 loss. Gronkowski fought through an attempted tackle by another Saints rookie, Marcus Williams, around the 10-yard line on his way to the end zone for the 69th receiving touchdown of his career (70th overall).
Gronkowski wasn't the only Patriot to suffer an injury.
Democrats urge full review of Republicans' 11th-hour attack on Obamacare
John McCain of Arizona told an MSNBC correspondent he might " reluctantly " vote for the measure offered by Sens. Compared with Paul, conservative groups have been fairly quiet on the bill.
Gostkowski missed his first PAT attempt of the game but connected on all six of his next kicks (three PATs, three field goals). Without Dont'a Hightower, it was good to see Matt Patricia's defense come up big. The Saints could mix and match their coverage plans for the highly productive tight end, but Vaccaro's strength and coverage skills likely make him the best option for the task. CB Marshon Lattimore, the Saints' No. 1 pick, was put under the concussion protocol after a fourth-quarter tackle.
The 40-year-old Brady hasn't often looked better in his long, illustrious career, providing an audible contingent of traveling Patriots fans who chanted their star QB's name ample reason to spend the rest of their Sunday celebrating on Bourdon Street.
Kickoff is 1 p.m.in Foxboro.
UP NEXT - New England returns home to face the Houston Texans.