The referee made use of the new Video Assistant Referee technology in the first half, as a Portugal goal was disallowed.
Just eight minutes later, Javier Hernandez scored the equaliser for Mexico.
Cedric Soares' 86th-minute shot was deflected in, but Hector Moreno snatched a point in the 91st minute.
Portugal captain Cristiano Ronaldo lamented his side's failure to close out victory over Mexico after conceding an injury-time equaliser in yesterday's 2-2 draw at the Confederations Cup.
Host Russia tops the group with three points after defeating New Zealand 2-0 in the opening match of the FIFA Confederations Cup on Saturday. Both teams will be looking for the three points after Russian Federation came away with a win against New Zealand in the first game of the competition.
"Cristiano Ronaldo is a great player but he's not the only one".
Ronaldo was making the headlines on Friday, two days before Portugal's Confederations Cup debut in Russian Federation, because of a report that said he wants to leave Real Madrid and Spain following allegations that he defrauded the country's tax authorities.
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Burling again showed why he's so highly regarded in world sailing, winning another start over Jimmy Spithill and Oracle. New Zealand continued to excel in light-wind sailing and again showed superior speed over the US boat.
While the VAR appeared to come to the correct decision, Santos was frustrated that this came only after the officials had looked at an earlier phase of play where Pepe was offside. "There are very strong national teams in this tournament", Silva said.
Mexico fully deserved a share of the spoils against Portugal as a reward for taking the game to the European champions, according to El Tri head coach Juan Carlos Osorio.
He said: "It was not the result we wanted, the team had the game nearly won and we conceded a goal in the last minutes, but that is football. Through that we will run less and defend less, so I think my teammates will be fired up to play a good game", ESPN quoted Salcedo as saying.
Whether it was the right flank in the first half or the left in the second half, Quaresma was quite easily the most menacing of attacking players for Portugal ahead of the much fancied Ronaldo.
In the 86th minute, Portugal broke through, scoring what they thought would be a victor. Portugal's lone loss in this span was a 3-2 defeat against Sweden at home.
Raphael Guerreiro missed a cross at the far post which gave Carlos Vela the chance to hook the ball back across for Hernandez to power home a diving header.
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