The 30-year-old Leicester City striker sustained the minor injury to his quad during training with Gareth Southgate's squad earlier in the week, and the Football Association released a statement to confirm his absence from Saturday's World Cup Group F qualifier against Scotland at Hampden park and Tuesday's friendly worldwide against France in Paris.
The Scots have won only one of their last 10 meetings - and lost the return fixture 3-0 at Wembley in November.
But Mulgrew insists the Scots are "feeling good" after some hard training sessions before the Hampden Park match.
"It is a huge challenge ahead, England are a great team and we will be massive underdogs", said Mulgrew.
"As I say, England have great players, really top players".
"One of these days they are going to be a great team and we have to guard against it being on Saturday".
"The standard is very high, the tempo is very high. During a game you want different people to step forward, whether that's with the ball or influencing others". Just place your bets on the enhanced market which is now available on the usual Scotland v England page here.
Antoine Griezmann: Atletico Madrid exit would be 'dirty move'
There is still a handsome season to be done and we hope to get some new signings in January. Because their squad is capable of handling the challenge.
Kane's last England goal came against Turkey in a Euro 2016 warm-up more than a year ago and the tournament would prove a major disappointment, being substituted at half-time in their solitary victory at the finals.
He said: "I think it would be as important as any".
"I want to get back playing, hopefully get back scoring". Things like that I think can help.
This enhanced quote is open to anyone with an account so whether you've taken up such a price boost before - such as Real Madrid to win and over 2.5 goals at 4/1 (5.0) in the Champions League final - or you're a new player, you're still eligible for an industry best price of 9/2 (5.50). "When you look in the old days, there was quite a lot of players down in England who played in what was then the First Division, at the likes of Arsenal, Spurs, United and City", Law said.
MARK McGHEE has dismissed the England squad's commando raid to toughen up for a Hampden assault and responded at the double: Our training is FAR tougher. He is getting fitter all the time and he knows age is only a number. "He is looking the best I have seen him".
Scotland trail group leaders England by six points, and are two points adrift of second-placed Slovakia, with four more qualifiers left after Saturday's game.
There are nine European qualifying groups with each winner reaching next year's finals while the eight runners-up with the best record go into a play-off with the four victors also going to Russian Federation.
Comments