If United fail to win the Europa League and finish outside the Premier League's top four they will not play in Europe's most prestigious club competition for the second season in a row.
And Mourinho again highlighted his supporters' efforts ahead of the crucial continental clash, lamenting a lack of atmosphere at their previous Europa League game against Anderlecht, in comparison to their recent Premier League win over champions-elect Chelsea.
"And for this group of players, we have just a little group with European success, I think Wayne Rooney, Michael Carrick, Young, this group of English boys with a long time in the club plus [Juan] Mata".
Despite being outclassed and outfought in the north London derby against Tottenham last week, Wenger chose to stick with the 3-4-3 formation for Sunday's game at the Emirates Stadium and it was a success as it gave the French manager his first ever league win over Jose Mourinho.
I left Highbury, they were crying, I left Emirates Stadium, they were crying. You think I enjoy a big club like Arsenal not winning trophies? Honestly, I'm not enjoying that.
Arsene Wenger publicly criticised Xhaka, who joined from Borussia Monchengladbach for £35mn in the summer, after the player was sent off for the second time of the season against Burnley in January and advised him "not to tackle". He's a big manager. I really don't care about it today.
"It's something that we are all disappointed about but hopefully it will give us a good end to the season". They were walking the streets with their heads low.
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Thierry Henry believes Jose Mourinho will have the last laugh at Manchester United if they manage to win the Europa League this season.
"I see a difference between games", Mourinho told a news conference.
United now sit four points adrift of neighbours Manchester City in fourth and may even be overtaken by the Gunners in the table should they beat Southampton on Wednesday.
"It doesn't matter what happened before, it doesn't matter how big matches we played before".
"It's up to us, we need some luck along the way, but if we win the next four games, I'm convinced that we can do it".
Hopes are the team can continue to reach their goals in the Europa League as favourites to win the competition.
"Herrera played every game".