Mourinho lost Marcos Rojo and Zlatan Ibrahimiovic to injury during yesterday's Europa League quarterfinal win over Anderlecht, the pair joining Phil Jones, Chris Smalling and Juan Mata on the sidelines.
Daley Blind replaced Rojo in the first half and Mourinho said that the Netherlands defender was a suitable deputy if the Argentina worldwide were to miss extended time, while adding that Phil Jones and Chris Smalling are nearing returns from injuries of their own.
United are awaiting the outcome of tests on Ibrahimovic, whose right knee locked against Anderlecht, and Rojo, who injured his left leg, with Mourinho admitting he was fearing the worst. "We had [on Thursday] an example of how hard it is [in the Europa League] and we now have a Spanish team, a French team and Ajax [in the semi-final draw], so we are not expecting anything easy". "That is the way we think", Mourinho added.
Manchester United manager Jose Mourinho has provided a team news update ahead of Sunday's Premier League trip to Burnley, admitting the team's defensive injury problems are mounting. "I am exhausted, I imagine the players are more exhausted than me, but we are in the [semi-final] draw [on Friday] and we still have the dream to win the competition".
Rooney returned to the bench against Anderlecht following ankle issues and Mourinho says his captain can have a big influence in the closing weeks of the campaign.
"So Herrera is fresh to play". Ashley Young is fresh to play. Nobody else is fresh to play.
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It was his third goal in his last four appearances. Ibrahimovic was removed from the game with United locked in a 1-1 draw with the Belgian side, just before extra time.
Mourinho again voiced reservations about the prospect of the 19-year-old being called up by England for this year's Under-21 European Championship.
"I haven't had much game time recently and I think, especially with the 120 minutes [on Thursday], it will help a lot with my fitness levels", Shaw told MUTV.
"Zlatan is not the type of character to play 25-26 games against the weaker opposition, not against the top teams and that will hurt him".
But Mourinho admitted "the power" is in the Football Association's hands over the decision.