Atletico Madrid struck in the first half at home to English Premier League champions Leicester City.
Though no one had given the Foxes any kind of hope to spring a positive result at the Vicente Calderon, Leicester did well to stay in the hunt as they lost out just 1-0 against an in-form Atletico side. The important thing is that the second leg will be open.
Simeone said: "He's a fabulous player, he's a complete player, you don't know what position he plays anymore. The conversation will be with Wes and our medical department and we'll give him every opportunity between now and then but if he's not ready we won't take a gamble", Shakespeare said.
"The message is that mentally and physically we have been in a game and have given a good account of ourselves". It was provoked but it did get a bit tasty so we left. They're just W0-D2-L3 when travelling to top-six teams in La Liga this term as they failed to keep a clean sheet in any of these games so as well as siding with the Foxes Draw No Bet, we're backing Over 2.5 Goals at 2.1.
"The second leg? I think they'll have more of the ball and take more risks, so we'll have to be flawless defensively. That is what we expected in the game".
Captain Wes Morgan is also battling a back injury and remains a doubt, with Yohan Benalouane the only recognised centre-back now available.
Manchester United legend Roy Keane talking on ITV's Champions League Show said: "I think Atletico will be happy to take them back them back to the King Power".
"I'd like to find out from the player, but my eyes tell me today that we should both be fairly pleased with the way he's come through".
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The referee judged Marc Albrighton's foul on Antoine Griezmann inside the penalty area.
"We have to get on with it".
Former Manchester United and England defender Rio Ferdinand was full of praise for City boss Craig Shakespeare.
"I think it is a disappointing moment, a key moment". The referee has to get that one right, you can't guess. "That's my intent for tomorrow and going forward".
Despite being a goal behind and facing the might of last year's finalists, Shakespeare was optimistic about his side's chances. "We lost 1-0 but we know at home it will be hard for Atletico".
Spanish police said eight Leicester fans were arrested for "causing a mess" on Tuesday night.
"That's what everyone is expecting from us anyway, what they expected last season".
He said: "We're a confident team".