David Letterman hummed a couple of Pearl Jam songs and declared, "I can't tell you what an honor and a privilege it is for me to be out of the house, honest to God", before standing in for Neil Young who was slated to induct the band.
Tupac joined the likes of ELO, Journey, Joan Baez, Nile Rodgers of Chic, Pearl Jam, and Yes for the class of 2017.
"Shoot, honey, I thought you were sitting down in the front, " Vedder said to laughs.
Speaking of rappers, Shakur - who died in 1996 - was remembered by Snoop Dogg with a touching and playful speech.
As one can see from the trailer above, Tupac's layered career, which included groundbreaking work in hip hop, acting, and social activism, skyrocketed him to rare, generation defining status of fame, and an equally infamous death that is still debated over and rumored about 21 years later.
Snoop Dogg did the honor of inducting Tupac into the Hall of Fame with a speech chronicling their relationship, including the story of Tupac passing Snoop his first blunt. Later, Alicia Keys performed a medley of Shakur's songs on piano, including "Dear Mama" and "Changes".
Yordano Ventura will be in the Royals' hearts during their home opener
Ventura's mother, Marisol Hernandez, took the mound to throw out the ceremonial first pitch, wearing her son's No. 30 jersey. The A's are 5-2 in his starts, he's pitched at least six innings five times and he's allowed one run or less five times .
Aside from the hope that Bob Dylan might show up to salute Baez, the biggest question of the night was whether vocalist Steve Perry would appear and perform with his former group Journey.
Perry, estranged from the band for many years, did embrace guitarist and cofounder Neal Schon onstage.
Harrison said that the Electric Light Orchestra was the first concert he attended as a child and it felt "more like witnessing a 21st-century exterrestrial spaceman wielding freaky instruments". Instead, Arnel Pineda sang lead as the band performed its hits, including "Don't Stop Believin'". You will always be right with us.
Even more unlikely remarks came from Rick Wakeman, the keyboardist from Yes, which in its heyday in the 1970s was rarely described as light-hearted. Arguments crop up around the long list of potential nominees that are revealed every year and then another argument starts when they let us all know who is getting in.
Tributes were also paid on Friday to Chuck Berry, who died last month at age 90 and who was the first person ever to be inducted in the Rock and Roll Hall of Fame in 1986, and Prince, who died of an accidental painkiller overdose in April 2016.
Artists are eligible for induction 25 years after the release of their first recording. Inductees will eventually be enshrined in the Rock and Roll Hall of Fame museum in Cleveland.