Sixth seed Sindhu could not muster a challenge against Chinese Taipei's top seed Tai Tzu Ying as she lost 14-21, 10-21 in 34 minutes.
London Olympics bronze medallist Saina also notched up a comfortable 21-18 21-10 win over Germany's Fabienne Deprez in 35 minutes. In the men single's Indian campaign ended with the defeat of H.S Prannoy to Tian Houwei of china. But she couldn't prevent losing the first set as the Korean won 22-20.
It was a heartbreaking loss for Saina who came close but could not pull it off at critical junctures at the Barclaycard Arena. However, Sindhu defeated her on her way to winning the Rio Olympic silver medal. In the second game, the game turned out to be much more easier as Sindhu raced to victory conceding only four points. The 21-year-old Sindhu continued her attacking spree and earned nine successive points without any fuss.
Sindhu zoomed to a 9-0 lead before the 23-year-old Indonesian bagged three points on the trot. But for the first few points in the first game Sindhu hardly matched the Taipei girl. She looked better as the game progressed that helped her take a 12-8 advantage. Tai fought back to level at 10-10 before going into the break with a one-point lead.
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When they realized they could play at a higher level, they asked for releases but were denied, so it was off to prep school. The two teams last played each other in 2000 at the Knapp Center in a tight contest won by Kansas State, 69-63.
The win was Sung's only second triumph in eight games against 2012 London Olympic bronze medal victor Saina.
After the change of ends, Tzu-ying opened up a 6-2 lead with Sindhu's strokes going to the net.
Sindhu and Ayustine were tied at 4-4 initially but after that the Indian broke off and left her opponent far behind to go one game up.